Graves' Disease is a veritable treasure trove for dermatologic signs and symptoms. So many of the signs the old dermatologists and internal medicine docs used to look for are now obviated by routine thyroid panels, well before the thyroid disease declares itself by hair loss, hyperhidrosis, melanoderma, Plummer's nails or the like. In other words, the lab rats are stealing our thunder!
Pretibial myxedema occurs in roughly 4% of cases, presumably due to thyroid stimulating antibodies which also trigger production of glycosaminoglycans pretibially, preradially and retroorbitally. The female to male ratio is 7:1. Bonus q: is Graves' Disease associated with hyper or hypothyroidism?